Recombinant asparaginase with antileukemic activity produced from yeast

Project 36

Problem to be solved:
• Severe immune response of the existing drug that has bacterial origin
• Technological dependence for the production of biopharmaceuticals

Proposed Innovation:
• Obtaining asparaginase from recombinant yeast
• Input production platform using recombinant yeast
• Alternative treatment for acute lymphoblastic leukemia

Differential:
• Decreasing side effects related to bacterial asparaginase
• Medicine without production of biosimilars in the country
• Reduction of production cost

Development status:
Prototype

Intellectual property status:
BRPI0406168-3

Technology transfer status:
Partnership

Coordinator:
Maria Antonieta Ferrara / Farmanguinhos

Contact:
Gestec/VPPIS – Phone: 21 3882-9099 / 3882-9120 or portfolio@fiocruz.br