MEDICINES / DRUGS

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Hybrid salts artesunate mefloquine (MEFAS) and primaquine (PRIMAS) for malaria treatment

Project 541

Problem to be solved
Obtain new drugs with a better pharmacokinetic and toxicological profile than those currently used for malaria.

Proposed innovation

  • Association of antimalarial drugs through new hybrid molecules.
  • Improve the toxicological profile of primaquine, only treatment option for the treatment of malaria from Plasmodium vivax.

    • Differential

  • More efficient treatment.
  • Less toxicity.
  • Lower cost of pharmochemical production.

    • Stage of development
    Laboratory scale

    Status of the intellectual property

  • BRPI 0401107-4, corresponding in the USA and India.
  • Patent awarded in the USA: US 8.071.777.

    • What we want
    Licensing

    Coordinator
    Núbia Boechat/ Farmanguinhos

    Contact
    Gestec/VPPIS – phone: 21 3882 9099/ 3882 9120 or portfolio@fiocruz.br